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PostPosted: Thu Apr 04, 2019 8:28 am Post subject: No icon Up to 60% off runescape cheapest gold as The first gift of s Reply with quote

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Kratom does affect opioid recepters, but in atypical ways. Like, mitragynine and 7 hydroxymitragynine are partial G protein biased agonists at the mu opioid receptor, which do not recruit B arrestin following receptor activation. They are also antagonists at the kappa and delta receptors. The other major alkaloids isolated from the plant, paynanthiene, speciogynine, and speciociliatine, all exhibited competitive MOR antagonist activity.
It has some hypothetical cross tolerance. But usually people are just in withdraw whenever they switch and pay more attention to alleviating that withdraw, which may simply take more of either substance. Just like using GABAergics to treat opioid withdraw or vice versa. So it kind of hard to get any real info on that.
I heard countless anecdotes that the same dose feels the same, like 10 20mg oxy OR 7 10g kratom will still feel nice even if you have a tolerance of the other, as long as they affect you individually. Or of people only taking 7g kratom and still feeling great relief from say, 16mg daily suboxone dependence.
Not to say switching back and forth is any sort of free lunch, of course. Tolerance will probably build regardless. And anyone should probably still start with the lowest possible dose of anything for safety purposes, really.I noticed more issues between kratom and dissociatives than kratom and opiates. Like they make each other feel weaker, sometimes almost dysphoric, if used back to back or at the same time. And at stupid high doses,
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